QS-Cetirizine
83881-51-0
C21h25cln2o3
N/M
Negotiable
Normal
>12 Months
Cetirizine
Cetirizine
>99%
Cetirizine
Cetirizine Hydrochloride
White to off-White
White
Pharmaceutical Grade
HPLC 99%
Pharmaceutical
HPLC
C21h25cln2o3
388.89
1.237
110 -115 Oc
542.1 Oc
1.589
101 Mg/L
QS
Negotiable
negotiable
Xi'an
Product Description
Anti-Allergic Cetirizine HCl Pharmaceutical Raw Material Cetirizin
| Product name | Cetirizine |
| Cas number | 83881-51-0 |
| Appearance | White to Off-White |
| MF | C21H25ClN2O3 |
| MW | 388.89 |
- Cetirizine (Cetirizine) is a second generation H1 antihistamine that is a long-acting selective, oral and potent antiallergic drug. For seasonal or perennial allergic rhinitis, urticaria caused by allergens and skin itching.
Cetirizine had no effect on mast cells in allergen immunity tests, but inhibited neutrophil and platelet responses. Patients with a single dose of 20mg or less did not have severe drowsiness or cognitive behavioral changes. Cetirizine 10mg produced sedation similar to placebo, loratadine 10mg, terphenadine 120mg, but significantly weaker than oxamide 30mg or ketotifen 1mg. Cetirizine 5 ~ 20mg orally or multiple times had no damage to psychomotor behavior. But in one trial, cetirizine at a single dose of 10mg caused significant impairment in driving behavior.
Pharmacokinetics of cetirizine
Peak blood concentrations (257 and 580μg/L) of cetirizine were reached within 1h after oral administration of 10 to 20mg of cetirizine in healthy adults. Food slows the rate of absorption, but does not affect the degree of absorption. The effect can be maintained for 24h. Cetirizine is basically not metabolized in the body, and most of it is excreted in its original form by urine, stool, sweat, lotion, etc. The urine excretion rate accounted for 70%, stool accounted for 10%. All excreted within 2 days. Adults t1/2 is 7.4 ~ 11h, and children t1/2 is 6.2h, which is not easy to penetrate the blood-cerebrospinal fluid barrier.
