| Name | Adenosine triphosphate |
| Synonyms | 5'-Deoxyadenylate triphosphate; Adenosine 5'-triphosphate; [(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate |
| Molecular Structure | |
| Molecular Formula | C10H16N5O13P3 |
| Molecular Weight | 507.18 |
| CAS Registry Number | 56-65-5 |
| EINECS | 200-283-2 |
5' -adenosine triphosphate is a metabolite of adenosine, a multifunctional nucleoside triphosphate that is used in cells as an intracellular energy transfer coenzyme to transport chemical energy within the cell for metabolism.
ATP(5mM;1hour)co-treatmentwithLPS(1μg/mL)hasasynergisticeffectontheactivationoftheNLRP3inflammasomeinHGFs.ATP(2mM;0.5-24houChemicalbookrs)inducessecretionofIL-1β,KCandMIP-2fromBMDMsinacaspase-1activation-dependentmanner.ATPpromotesneutrophilchemotaxisinvitro.
ATP(50mg/kg;i.p.)protectsmiceagainstbacterialinfectioninvivo.ATPinducesthesecretionofIL-1β,KCandMIP-2andneutrophilsrecruitmentinvivo.AnimalModel:Four-weeChemicalbookk-oldKunmingmice(18-22g)Dosage:50mg/kgAdministration:Intraperitonealinjection,beforebacterial(E.coli)challengeResult:Protectedmicefrombacterialinfection.
