SWP-BX528
Yes
Customized
GMP, HSE, ISO 9001, USP, BP, SGS
Adult
Powder
>99%
Ibrutinib
White Powder
936563-96-1
C25h24n6o2
440.50
100g
HPLC
Available
Pharmaceutical Grade
2 Years
Cool and Dry Place
Sonwu
Vacuum Sealed Foil Bag
100g/bag
Shaanxi, China
Product Description
| Product Name | Ibrutinib |
| CAS | 936563-96-1 |
| Formula | C25h24n6o2 |
| MW | 440.50 |
| Purity | 99% |
| Appearance | White powder |
| Shelf life | 2 years |
| Storage | Cool and dry place |
Ibrutinib is a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm)
Ibrutinib is a kind of Bruton tyrosine kinase (BTK) inhibitor, it could be used for the chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). MCL and CLL are belonged to the B-cell non-Hodgkin's lymphoma, which is difficult to easy to recurrent. Common chemical immunotherapy does not have the targeting, often occurs 3 or 4 adverse reactions. Ibrutinib and B lymphocytes could target with BTK which is necessary for formation, differentiation, and transmission of information, inhibit BTK activity irreversibly, and inhibit cell proliferation and survival effectively. Ibrutinib could be rapidly absorbed after oral administration, during 1~2h reach maximum blood concentration, adverse reactions belong to one or two, therefore, Ibrutinib will become a new choice for the CLL and MCL.| Similiar product recommendation | |||
| Estriol | Progesterone | Phytoestrogens | Vitamin D |
| Medroxyprogesterone Acetate | Megestrol Acetate | Mifepristone | Megestrol |
| 17a-Hydroxyprogesterone caproate | Dienogest | Algestone acetophenide | Allylestrenol |
| 17a-estradiol | Estradiol Cypionate | 2-Methoxyestradiol | Estradiol Benzoate Butyrate |
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