Introduction:
Sirolimus (Rapamycin) is a potent immunosuppressant and antiproliferative agent that is widely used in medical applications. It was first discovered in the soil of Easter Island and has since become an important drug in the field of transplantation and cancer treatment.
Function:
Sirolimus functions by inhibiting the activity of a protein called mTOR (mammalian target of rapamycin). This protein plays a crucial role in cell growth, proliferation, and immune response. By blocking mTOR, sirolimus suppresses the immune system, preventing organ rejection in transplant patients. Additionally, it exhibits antiproliferative properties, inhibiting the growth and division of cancer cells.
Application:
The applications of sirolimus are diverse and significant. In transplantation medicine, sirolimus is used as an immunosuppressant to prevent the rejection of transplanted organs, such as kidney, liver, and heart. It is often used in combination with other immunosuppressive medications to achieve a synergistic effect.
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