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The NIES (Integrated Nose-only Inhalation Exposure System) is a state-of-the-art solution for inhalation exposure studies, designed to convert liquid or solid samples into inhalable aerosols and deliver them precisely to the respiratory zones of animals via a controlled nose-only exposure chamber. This advanced system ensures uniform aerosol distribution, minimal sample waste, and reliable results, making it an ideal choice for GLP-compliant inhalation toxicity testing, pharmacokinetics, and respiratory disease modeling.
Typical Applications:
- Inhalation pharmacokinetics/pharmacodynamics (PK/PD) studies
- Respiratory disease modeling
- Drug safety evaluation research
- GLP-compliant studies
- Long-duration experiments and large-scale inhalation exposure studies
- Inhalation toxicology research
- Drug development
- Environmental health research
- Tobacco-related research



Key Features
| Feature | Description |
| GLP-Compliant Inhalation Testing | Optimized for GLP inhalation toxicity testing with reliable and reproducible results. |
| Compact Footprint | Occupies only 1 square meter, ideal for laboratories with space constraints. |
| Deployment Flexibility | Offers two deployment options to accommodate various laboratory setups. |
| High Capacity | Supports up to 60 animals simultaneously, suitable for large-scale studies. |
| Long-Term Reliability | Operates for over 10,000 hours without failure, includes lifetime technical support. |
| Superior Concentration Uniformity | Ensures consistent exposure with a concentration error of less than ±8% between animal ports. |
| Precise Gas Flow Control | Controls aerosol generation, dilution, and exhaust flow for optimal exposure conditions. |
| Safe Emissions | Equipped with waste gas treatment for safe and compliant emissions. |
System Configuration
| Component | Description |
| Exposure Chamber | - Material: SUS316L medical-grade stainless steel |
| - Capacity: Up to 60 animals per chamber | |
| - Compatibility: Supports rats, mice, guinea pigs, and rabbits | |
| - Sample Types: Compatible with liquid, powder, and gas samples | |
| - Features: Quick assembly/disassembly for easy cleaning, supports various environmental sensors | |
| Rodent Restrainers | Designed for secure and comfortable positioning of animals during exposure. |
| Aerosol Generation Unit | Supports various aerosol nebulizers and dust generators, allowing flexibility in aerosol type and size. |
| Control/Monitoring System | Control Interface: 7" touch screen for easy operation, supporting both local and remote control modes. |
| Flow Control: High-precision multi-channel airflow control with connection options for multiple sensors. | |
| Software: Compliant with 21 CFR Part 11 standards, supporting electronic signatures, audit trails, multi-device control, and customizable reporting. | |
| Environmental parameters like temperature, humidity, and gas concentrations are measurable | |
| Exhaust System | The ASU Waste Gas Scavenging System ensures safe disposal of waste gas through filtration before exhausting. |
| Air Compressor | Optional - Silenced Medical Grade Oil-free Air Compressor available, including air compressor, air dryer, condensate drainage, oil separator, and filter. (User-configurable; customers may also use local air compressors) |


System Highlights
| Highlight | Description |
| Comprehensive GLP Validation | Ensures compliance with GLP standards, providing reliable data for regulatory submissions. |
| Expandable Functionality | Supports upgrades and system expansions as research needs evolve. |
| Integrated System Design | Combines all necessary components into an integrated system for streamlined operation. |
| Superior Core Components | Built with high-quality materials and components for long-lasting performance. |
Why Choose INHALOGIC NIES?
Exceptional Precision and Uniformity
Versatile and Customizable
Space-Efficient Design
User-Friendly Operation
Robust Reliability and Support
Compliance and Validation
Enhanced Safety Features
Comprehensive Data Management
Cost-Effective Operation
Global Expertise and Service
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