67727-97-3
C16h30n4o4
N/a
Synthesis Material Intermediates
Powder
Refined
White
Standard
Laboratory Reagents
Dry Powder
Fine Chemicals
Scientific Research
Protein and Peptide
Research Peptides
No Tfa Salt
Authoried Regluar Workshop
1g/Bottle
Research Use Only
Hoconbio
Customized
1G/Bottle 2mg/5mg/10mg per vial
China
Product Description
99% Pure Synthetic Tetrapeptide Ac-SDKP Peptide Raw Powder Goralatide Seraspenide Peptide Powder Ac-SDKP For Anti-inflammatory And Antifibrotic
| Product Name | Ac-SDKP |
| CAS NO. | N/A |
| Other name | goralatide / seraspenide |
| Appearance | White powder |
| Purity | 98% HPLC |
| Application | Research peptides |
| Shelf Life | 24 Months |
| Storage | Store at a temperature of 2-8 degrees, protected from light. |
Ac-SDKP peptide (also known as seraspenide or goralatide)
The synthetic tetrapeptide Ac-SDKP, also called seraspenide or goralatide, has the chemical structure 1-(N2-(N-(N-acetyl-L-seryl)-L-alpha-aspartyl)-L-lysyl)-L-proline, the molecular formula C20H33N5O9, and a molecular weight of 487.50412 dalton. This tetrapeptide is involved in angiogenesis and the regulation of the immune response by blocking the proliferation of lymphocytes.
Ac-SDKP is a natural tetrapeptide with anti-inflammatory and antifibrotic properties. It has been widely distributed in mammalian organs, plasma, urine, and circulating mononuclear cells. The peptide is hydrolyzed by angiotensin-converting enzyme (ACE) and has a short half-life of 4.5 min in the circulation. Treatment with ACE inhibitors significantly increases plasma concentration of Ac-SDKP, and some of the ACE inhibitors protective effects were reported to be mediated by the increases in Ac-SDKP concentrations. In animal diseases with hypertension, as well as cardiovascular and kidney disease, Ac-SDKP reduces inflammatory cell infiltration and collagen deposition in the heart, kidney, lung, and liver. The peptide has potential applications in the treatment of various inflammatory and fibrotic diseases.
